![]() Copy number variation in syndromic forms of psychiatric illness: the emerging value of clinical genetic testing in psychiatry. I., van Zutven, L., van Minkelen, R., … Kushner, S. 21st-Century genetics in psychiatric residency training. ![]() American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 180, 335-340. Exome sequencing of sporadic childhood-onset schizophrenia suggests the contribution of X-linked genes in males. Īmbalavanan, A., Chaumette, B., Zhou, S., Xie, P., He, Q., Spiegelman, D., … Rouleau, G. High rate of disease-related copy number variations in childhood onset schizophrenia. © 2020 International Society for Autism Research, Wiley Periodicals, LLC.Īhn, K., Gotay, N., Andersen, T. © 2020 International Society for Autism Research, Wiley Periodicals, Inc.Īutism spectrum disorder child psychiatry genetic testing inpatients medical genetics neurodevelopmental disorders. These results tell us that the psychiatric hospital may be a good place for children with autism and behavioral problems to get genetic testing, but that it is really important that doctors assure follow-up is feasible for all patients to receive their genetic test results once they leave the hospital. However, many children did not end up receiving their genetic test results once they left the hospital. We identified a genetic risk factor in a small percentage of children and a possible genetic risk factor in a large percentage of children. We provided genetic testing to a group of these children who were in a psychiatric hospital by teaching their doctors how it can be helpful. LAY SUMMARY: Genetic testing is recommended for children with autism and related developmental conditions. Genetic testing on an inpatient CAP service may also improve access to genetic services for underrepresented minorities, but assuring outpatient follow-up can be challenging. This preliminary evidence also suggests that genetic testing for inpatients may identify variants of unknown significance instead of well-known neurodevelopmental disorder risk variants. We have demonstrated that it is feasible to provide medical genetics education to CAP fellows on an inpatient service, which may improve genetic testing rates. 43.5% of patients were lost to outpatient genetics follow-up. 39.1% of patients who received genetic testing while inpatients were underrepresented minorities, compared to 7.7% of inpatients who received genetic testing from other clinical services. However, 34.8% had variants of unknown significance. Genetic risk factors were identified in 4.3% of inpatients. The genetic testing rate on the inpatient CAP service was 1.6% before the educational intervention and 10.7% afterward. We compared demographics to similar patients who received testing on other clinical services and assessed rates of outpatient genetics follow-up post-discharge. We provided medical genetics education to CAP fellows and retrospectively compared the genetic testing rates and diagnostic yield pre- and post-education. ![]() One approach to improve access to genetic testing is to offer it on the inpatient child and adolescent psychiatry (CAP) service. Diagnostic genetic testing is recommended for children with autism spectrum disorder and other neurodevelopmental disorders.
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